Tetrahedron Letters p. 3315 - 3318 (1982)
Update date:2022-08-02
Topics:
Krishnamurthy, S.
Formylation of functionalized primary aromatic and aliphatic amines with acetic formic anhydride (AFA) followed by borane:methyl sulfide reduction in the same pot affords the corresponding N-methylamines in excellent isolated yields, uncontaminated by bis alkylation; the reaction sequence is applicable to even very weakly basic and sterically hindered amines.
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