Folate analogues. 21. Synthesis and antifolate and antitumor activities of N10-(cyanomethyl)-5,8-dideazafolic acid

DOI: 10.1021/jm00358a030

Source and publish data:

Journal of Medicinal Chemistry p. 605 - 607 (1983)

Update date:2022-08-04

Topics:

Authors:

Nair Nair

Salter Salter

Kisliuk Kisliuk

Gaumont Gaumont

North North

Sirotnak

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Article abstract of DOI:10.1021/jm00358a030

A close analogue of the antileukemic agent 5,8-dideaza-N¹⁰ propargylfolic acid (2) was synthesized by replacing the propargyl moiety of 2 with a cyanomethyl group. This compound, N¹⁰-(cyanomethyl)-5,8-dideazafolic acid (3), was evalu

Full text of DOI:10.1021/jm00358a030

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