Synthesis of 1-methyl-4-(N-aroyl)-piperidinamides with anti- inflammatory and analgesic activities

DOI: 10.1016/S0014-827X(98)00016-0

Source and publish data:

Il Farmaco p. 233 - 240 (1998)

Update date:2022-07-30

Topics:

Authors:

Pau, Amedeo

Boatto, Gianpiero

Cerri, Riccardo

Palagiano, Francesco

Filippelli, Walter

Falcone, Giuseppe

Lampa, Enrico

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0014-827X(98)00016-0

Two series of 1-methyl-4-(N-aroyl)-piperidinamides were synthesized and evaluated for their anti-inflammatory and analgesic properties, as well as for their gastrointestinal irritation liability. A non-aromatic derivative, 1-methyl-4-(N-cyclohexanoyl)-piperidinamide, was synthesized and evaluated in order to obtain a more exhaustive knowledge of the structure-activity relationship.

Full text of DOI:10.1016/S0014-827X(98)00016-0

Products guided by the article

Product name:1-METHYL-4-PIPERIDONE OXIME HYDROCHLORIDE

Cas No:84540-61-4

R&D Labs maybe for 84540-61-4

Weifang Yuexiang Chemical Co.,Ltd

Contact:86-536-8734188

Address:Economic development zone Weifang city ,Shandong province ,China
XI'AN CHUKANG BIOTECHNOLOGY CO.,LTD

Contact:29-63685658 63685359

Address:Room 3-1202,Building 1,Oriental oasis,East of Xianning Road,Xi'an,Shaanxi 710043 P.R.China
Taizhou Crene Biotechnology co.ltd

Contact:86-576-88813233 88205808

Address:Economic Developed Zone of Taizhou Zhejiang China
Ji'an Kexin Trade Co., Ltd.(expird)

Contact:86-0796-8187704 18507063190

Address:ji'an jiangxi
TIC Gums, Inc.

Contact:410-273-7300; 800-221-3953

Address:4609 Richlynn Dr., PO Box 369, Belcamp, MD, 21017-0369, USA

Relevant to this article

Enantioselective total synthesis of antiangeogenic pentaketide dimers, epoxyquinols A and B, through an asymmetric aldol approach to their common monomeric precursor

Doi:10.1016/j.tetlet.2004.12.001
(2005)
Sulfone reagents in organic synthesis. VI. Sulfonyl- and silyl-substituted hydrocarbons as versatile carbanion precursors in organic synthesis

Doi:10.1016/0022-328X(85)87362-9
(1985)
Studies on fluorinated pyrimidines. V. Preparation of optically active (+)-and (-)-t-6-butoxy-r-5-ethoxycarbonyl-5-fluoro-5,6-dihydrouracils

Doi:10.1248/cpb.30.3005
(1982)
Syntheses of peptide alkaloids. VI. Amino acids and peptides. XXXVII. Total synthesis of 9,10-dihydrozizyphine G

Doi:10.1002/jlac.198219821206
(1982)
Organocatalytic decarboxylative Doebner-Knoevenagel reactions between arylaldehydes and monoethyl malonate mediated by a bifunctional polymeric catalyst

Doi:10.1055/s-0030-1260808
(2011)
Palladium Nanoparticles-Catalyzed Synthesis of Indanone Derivatives via Intramolecular Reductive Heck Reaction

Doi:10.1002/adsc.201900752
(2019)

Article Doi