Synthesis of 1-methyl-4-(N-aroyl)-piperidinamides with anti- inflammatory and analgesic activities

Article abstract of DOI:10.1016/S0014-827X(98)00016-0

Two series of 1-methyl-4-(N-aroyl)-piperidinamides were synthesized and evaluated for their anti-inflammatory and analgesic properties, as well as for their gastrointestinal irritation liability. A non-aromatic derivative, 1-methyl-4-(N-cyclohexanoyl)-piperidinamide, was synthesized and evaluated in order to obtain a more exhaustive knowledge of the structure-activity relationship.