Synthesis of 1-methyl-4-(N-aroyl)-piperidinamides with anti- inflammatory and analgesic activities

DOI: 10.1016/S0014-827X(98)00016-0

Source and publish data:

Il Farmaco p. 233 - 240 (1998)

Update date:2022-07-30

Topics:

Authors:

Pau, Amedeo

Boatto, Gianpiero

Cerri, Riccardo

Palagiano, Francesco

Filippelli, Walter

Falcone, Giuseppe

Lampa, Enrico

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Article abstract of DOI:10.1016/S0014-827X(98)00016-0

Two series of 1-methyl-4-(N-aroyl)-piperidinamides were synthesized and evaluated for their anti-inflammatory and analgesic properties, as well as for their gastrointestinal irritation liability. A non-aromatic derivative, 1-methyl-4-(N-cyclohexanoyl)-piperidinamide, was synthesized and evaluated in order to obtain a more exhaustive knowledge of the structure-activity relationship.

Full text of DOI:10.1016/S0014-827X(98)00016-0

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