Considerations to the synthesis of methadone-nitrile as well as isomethadone-nitrile, and related compounds

Article abstract of DOI:10.3797/scipharm.aut-00-21

The 2-chloro-1-dialkylamino-propanes 4a-d are reacted with diphenylacetonitrile under phase transfer conditions to give a mixture of the nitriles la-d and 2a-d. Both chloro-dialkylamino-1-phenyl-ethanes 7a-d and 8a-d lead to 4-dialkylamino-2,2,3-triphenyl-butyronitriles 6a-d.