Synthesis of analogues of pepstatin. Effect of structure in subsites P(1'), P(2'), and P(2) on inhibition of porcine pepsin

DOI: 10.1021/jm00360a022

Source and publish data:

Journal of Medicinal Chemistry p. 904 - 910 (1983)

Update date:2022-08-04

Topics: Enzyme Kinetics Substrate Structure-Activity Relationship Inhibition

Authors:

Rich Rich

Salituro

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Article abstract of DOI:10.1021/jm00360a022

A series of pepstatin analogues having structural variations in the P(2'), P(1'), and P(2) positions have been synthesized and tested for inhibition of porcine pepsin. The standard peptide for this study was Iva-Val-Sta-Ala-Iaa. Structural variations in t

Full text of DOI:10.1021/jm00360a022

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