An Unusual Migratory Aptitude in a Cyclopropylcarbinyl-Cyclobutyl Rearrangement. Synthesis of 2,4-Disubstituted Cyclobutanones

DOI: 10.1021/jo00155a050

Source and publish data:

Journal of Organic Chemistry p. 1131 - 1133 (1983)

Update date:2022-07-30

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Authors:

Trost, Barry M.

Ornstein, Paul L.

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Article abstract of DOI:10.1021/jo00155a050

The inductive effect of an (acyloxy)methyl substituent encourages migration of the less substituted carbon in the Grignard adducts of (E)-2-(hydroxymethyl)-1-(phenylthio)cyclopropane-1-carboxaldehyde.

Full text of DOI:10.1021/jo00155a050

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