Tetrahedron p. 501 - 509 (1984)
Update date:2022-09-26
Topics: Cleavage Nucleotide Experimental Interaction Binding DNA BLEOMYCIN
Umezawa, Hamao
Takita, Tomohisa
Sugiura, Yukio
Otsuka, Masami
Kobayashi, Susumu
Ohno, Masaji
Biosynthetic intermediates and synthetic analogues of bleomycin (BLM) have been investigated for their metal binding, dioxygen activation, and DNA cleavage.Molecular O2 was activated by the Fe(II) complex of a synthetic model ligand.Nucleotide sequence sp
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