MedChemComm
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COMMUNICATION
Journal Name
presence of 10% Pd/C (728 mg) at ambient temperature for 6 h
under a pressure of 4 atm. The reaction mixture was then diluted
with AcOEt (15 mL), filtered through Celite and the filtrate
concentrated in vacuo to give the desired primary amine, which was
then used without further purification.
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DOI: 10.1039/C8MD00604K
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General Procedure for the Preparation of Amides
Solution of corresponding amine (2.32 mmol) in dry
dichloromethane (10 mL) was treated with triethylamine (0.5 mL) at
0 °C. The appropriate anhydride (3.48 mmol) was then added
dropwise at the same temperature, and the resulting reaction mixture
was left stirring at room temperature for 1.5 h. The solution was then
poured into a separatory funnel, CH2Cl2 was added, and the yellow
organic layer was washed with H2O (20 mL). After drying over
Na2SO4, the solvent was evaporated under reduced pressure to give
the crude product, which was chromatographed (flash column) to
give the desired amide.
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4 | J. Name., 2012, 00, 1-3
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