A novel theranostic activity-based probe targeting kallikrein 7 for the diagnosis and treatment of skin diseases

DOI: 10.1039/d1cc01673c

Source and publish data:

Chemical Communications p. 6507 - 6510 (2021)

Update date:2022-08-03

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Authors:

Bisyris, Evangelos

Zingkou, Eleni

Kordopati, Golfo G.

Matsoukas, Minos

Magriotis, Plato A.

Pampalakis, Georgios

Sotiropoulou, Georgia

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Article abstract of DOI:10.1039/d1cc01673c

We applied a newin silicoapproach for using protease-substrate motifs to design a kallikrein 7 (KLK7)-specific phosphonate activity-based probe (ABP) to quantify the active KLK7in situ. Epidermal application of the ABP-inhibitor onSpink5^?/?Klk5

Full text of DOI:10.1039/d1cc01673c

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