Novel Zinc-Promoted Alkylation of Iminium Salts. New Synthesis of Benzylisoquinoline, Phthalidylisoquinoline, and Protoberberine Alkaloids and Related Compounds

DOI: 10.1021/jo00158a010

Source and publish data:

Journal of Organic Chemistry p. 1621 - 1628 (1983)

Update date:2022-08-05

Topics:

Authors:

Shono, Tatsuya

Hamaguchi, Hiroshi

Sasaki, Manji

Fujita, Shumei

Nagami, Kimihiko

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Article abstract of DOI:10.1021/jo00158a010

Zinc-promoted reductive coupling reaction of iminium salts with alkyl halides was found to be a successful key reaction for synthesis of a variety of alkaloids such as benzylisoquinoline, phthalidylisoquinoline, and protoberberine alkaloids.More specifically, laudanosine, cordrastine, hydrastine, narcotine, tetrahydropalmatine, and canadine were obtained.A new route for the synthesis of the emetine and yohimbine skeletons was exploited.

Full text of DOI:10.1021/jo00158a010

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