Synthesis of 15β-hydroxyalkyl-substituted (17Z)-pregn-17-enes, their ethers and esters

Article abstract of DOI:10.1007/s11178-005-0067-4

Proceeding from Δ¹⁵-17-ketosteroids via copper(I)-catalyzed 1,4-addition of Grignard reagent followed by modification of the 15-alkenyl substituent, introduction of a 17-ethylidene component via Wittig reaction, and transformations in the A and B rings of the steroid molecule we obtained a series of 15β-hydroxyalkyl-substituted (17Z)-pregn-17-enes, their ethers and esters. 2004 MAIK "Nauka/Interperiodica".