Journal of the Chemical Society, Dalton Transactions p. 3107 - 3112 (1994)
Update date:2022-08-03
Topics:
Bayada, Anne
Lawrance, Geoffrey A.
Maeder, Marcel
O'Leary, Margaret A.
Copper(II)-directed condensation between 4,7-diazadecane-1,10-diamine, formaldehyde and 1-nitro-3-(2-nitroethyl)benzene yielded the macrocyclic <10-nitro-10-(3-nitrobenzyl)-1,4,8,12-tetraazacyclopentadecane>copper(II) ion.Reduction (Zn,HCl) gave the pendant-arm macrocycle 10-(3-aminobenzyl)-1,4,8,12-tetraazacyclopentadec-10-ylamine as the hydrochloride salt.Condensation reactions with 1-nitro-4-(2-nitroethyl)benzene and 2-phenylnitroethane were also successful.The capacity of the aminobenzyl C-pendant introduced by this facile chemistry for covalent attachment has been examined by attachment of 10-(3-aminobenzyl)-1,4,8,12-tetraazacyclopentadec-10-ylamine to the acidic cation-exchange resin CM Bio-Gel A and to horse heart cytochrome c, employing a water-soluble carbodiimide coupling agent at pH 5 to promote amide formation.The attachment was probed by copper(II) complexation to the bound macrocycle and subsequent spectroscopic or voltammetric analysis.
View MorePharmaResources(Kaiyuan)CO,.Ltd
Contact:+86-21-50720028
Address:No.3, Beihuan Road, Economic Development District, Kaiyuan City, Tieling City, Liaoning Province, China 112300
Contact:+86-20-32051076
Address:1105,Building A, International Business Incubator,Science City
Contact:18669908765
Address:Zibo City, Shandong Province, P.R.China
Chongqing Rong＆Quan Pharmaceutical Technology Co. , Ltd.
Contact:86-023-65268721
Address:No. 7, Manshanhong Village, Pingdingshan, Shapingba District, Chongqing Province, China
Wuxi Forest Biological Co.,Ltd
Contact:+86-510-81602300
Address:Room 317,Building D, No.159 middle Chengjiang Road,Jiangyin Wuxi city.
Doi:10.1039/jr9370000043
(1937)Doi:10.1021/jacs.9b12296
(2020)Doi:10.1021/ja00352a016
(1983)Doi:10.1039/c3ra42266f
(2013)Doi:10.1007/BF00923882
()Doi:10.1016/S0040-4039(00)85745-7
(1982)
