Azaindole Derivatives. 63. Effect of the Solvating Capacities of Solvents on the Pathways of Reactions under the Conditions of the Hofmann Rearrangement

Article abstract of DOI:10.1007/BF00512815

It is shown that 1-benzyl-6-chloro-7-carbamoyl-5-azaindoline undergoes primarily normal skeletal rearrangement to give 1-benzyl-6-chloro-7-methoxycarbonylamino-5-azaindoline under the conditions of the Hofmann reaction in the presence of pyridine, whereas