Spiropiperidines. I. Synthesis of 1'-substituted spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one derivatives and evaluation of their antihypertensive activity

DOI: 10.1248/cpb.33.1129

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1129 - 1139 (1985)

Update date:2022-08-05

Topics:

Authors:

Takai Takai

Obase Obase

Teranishi

Karasawa

Kubo Kubo

Shuto Shuto

Kasuya Kasuya

Hashikami

Karashima

Shigenobu

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Article abstract of DOI:10.1248/cpb.33.1129

General synthetic methods for the preparation of 4-(2-aminophenyl)-4-hydroxypiperidine derivatives have been developed. The application use of these derivatives in the synthesis of 1'-substituted spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one derivati

Full text of DOI:10.1248/cpb.33.1129

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