Stereoelectronic Control of Intramolecular Michael Addition Reactions

DOI: 10.1021/ja00353a038

Source and publish data:

Journal of the American Chemical Society p. 5090 - 5095 (1983)

Update date:2022-07-30

Topics:

Authors:

Ellis, Graham W. L.

Johnson, C. David

Rogers, David N.

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Article abstract of DOI:10.1021/ja00353a038

Concepts of stereoelectronic control lead to the conclusion that the 5-endo-trig ring closure of (E)-2-methyl-3-oxo-5-phenylpent-4-en-2-ol should be disfavored.However, the acid-catalyzed ring closure in trifluoroacetic acid occurs readily, suggesting an

Full text of DOI:10.1021/ja00353a038

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