Journal of the American Chemical Society p. 8971 - 8973 (2005)
Update date:2022-08-03
Topics:
Denmark, Scott E.
Fujimori, Shinji
An enantioselective synthesis of the polyene macrolide RK-397 is described. The use of the same eight-carbon building block twice for the construction of the polyol chain allowed for a highly convergent synthesis. The synthesis highlights stereoselective vinylogous aldol addition using a chiral bisphosphoramide as well as a sequential palladium-catalyzed cross-coupling reaction for the preparation of key fragments. Copyright
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