Low-melting phenytoin prodrugs as alternative oral delivery modes for phenytoin: A model for other high-melting sparingly water-soluble drugs

DOI: 10.1002/jps.2600720420

Source and publish data:

Journal of Pharmaceutical Sciences p. 400 - 405 (1983)

Update date:2022-08-04

Topics:

Authors:

Yamaoka Yamaoka

Roberts Roberts

Stella Stella

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Article abstract of DOI:10.1002/jps.2600720420

Phenytoin is a high-melting, weakly acidic, and sparingly water-soluble drug. Because of these physicochemical properties, phenytoin is subject to erratic bioavailability in a variety of dosage forms both in its acidic as well as sodium salt forms. A homo

Full text of DOI:10.1002/jps.2600720420

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