Tetrahedron p. 749 - 756 (1984)
Update date:2022-08-05
Topics:
Maio, G. Di
Vecchi, E.
Zeuli, E.
Delfini, M
Alkylation of methyl 4-methyl 5-oxo 5-phenyl (m and p-X substituted) pentanoates 1a-h give cis and trans tetrahydro 5,6-dimethyl 6-phenyl 2H pyran-2-ones.LFER of isomer ratios as function of the X substituent on the phenyl ring is seen in MeLi-Et2O.The lactone ratios of the reactions in THF with MeMgCl are not affected by the X phenyl substituent, while a more complex situation is showed by reactions of MeMgCl in Et2O and benzene.Changes in the cis: trans-ratios with variations in reactant and solvent are discussed in terms of equilibrium between folded and unfolded conformations in transition states.
View MoreLuojiang Chenming Biological Products Co
Contact:+86 15000297032
Address:GROUP NO.4, HE SHENG VILLAGE, PANLONG TOWN,
Jinan Hongfangde Pharmatech Co.LTD
Contact:0531-88870908
Address:F Bldg,750#,Shunhua Rd,New&High-tech Zone,Jinan,Shandong,China 250101
Contact:027-87677569
Address:Room 2203, yujingmingmen Buidling One, xiongchu Road, wuhan city, hubei province, China
Zouping Mingxing Chemical Co.,Ltd.
website:http://www.zoutong.com.cn
Contact:86-543-2240068 2240067
Address:428 Daixi Third Road Zouping County Shandong Province China
He Bei Shun Er Chemical Co., LTD.
Contact:86-0311-86996932/86860168
Address:No 18,North street
Doi:10.1051/epjap:2000113
(1918)Doi:10.1016/j.tet.2005.04.051
(2005)Doi:10.1021/ja00354a046
(1983)Doi:10.1021/ol051126+
(2005)Doi:10.1016/j.farmac.2004.07.014
(2004)Doi:10.1021/jo00164a018
(1983)
