SYNTHETIC STUDIES ON CARBAPENEM ANTIBIOTICS FROM PENICILLINS. III. STEREOSELECTIVE RADICAL REDUCTION OF A CHIRAL 3-ISOCYANOAZETIDINONE: A TOTAL SYNTHESIS OF OPTICALLY ACTIVE CARPETIMYCINS

Article abstract of DOI:10.1016/S0040-4039(00)61885-3

A new, efficient synthesis of the optically active carpetimycins 1 from penicillins has been achieved via, as key steps, aldol reaction of isonitrile 19, followed by n-Bu3SnH reduction.