Systematic SAR study of the side chain of nonsecosteroidal vitamin D 3 analogs

DOI: 10.1016/j.bmc.2012.05.023

Source and publish data:

Bioorganic and Medicinal Chemistry p. 4495 - 4506 (2012)

Update date:2022-08-05

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Authors:

Kashiwagi, Hirotaka

Ono, Yoshiyuki

Ohta, Masateru

Morikami, Kenji

Takahashi, Tadakatsu

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Article abstract of DOI:10.1016/j.bmc.2012.05.023

A series of nonsecosteroidal vitamin D₃ analogs with carboxylic acid were explored. Through our systematic SAR studies on the side chain moiety, compound 6b was identified as the optimal compound showing excellent vitamin D receptor (VDR) agoni

Full text of DOI:10.1016/j.bmc.2012.05.023

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