Design of anticandidal agents: Synthesis and biological properties of analogues of polyoxin L

DOI: 10.1021/jm00364a030

Source and publish data:

Journal of Medicinal Chemistry p. 1518 - 1522 (1983)

Update date:2022-08-04

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Authors:

Shenbagamurthi

Smith Smith

Becker Becker

Steinfeld

Naider Naider

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Article abstract of DOI:10.1021/jm00364a030

Six analogues of polyoxin L were synthesized from uridine. All of these analogues inhibited chitin synthetase from Candida albicans. Derivatization of the amine terminus of the polyoxin analogues resulted in loss of activity, and analogues containing arom

Full text of DOI:10.1021/jm00364a030

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