Investigation of functionally liver selective glucokinase activators for the treatment of type 2 diabetes

DOI: 10.1021/jm900839k

Source and publish data:

Journal of Medicinal Chemistry p. 6142 - 6152 (2009)

Update date:2022-08-03

Topics: Investigation Experimental Type 2 diabetes Glucokinase activators

Authors:

Bebernitz, Gregory R.

Beaulieu, Valerie

Dale, Bethany A.

Deacon, Richard

Duttaroy, Alokesh

Gao, Jiaping

Grondine, Melissa S.

Gupta, Ramesh C.

Kakmak, Mesut

Kavana, Michael

Kirman, Louise C.

Liang, Jinsheng

Maniara, Wieslawa M.

Munshi, Siralee

Nadkarni, Sunil S.

Schuster, Herbert F.

Stams, Travis

St. Denny, Irene

Taslimi, Paul M.

Vash, Brian

Caplan, Shari L.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm900839k

Type 2 diabetes is a polygenic disease which afflicts nearly 200 million people worldwide and is expected to increase to near epidemic levels over the next 10-15 years. Glucokinase (GK) activators are currently under investigation by a number of pharmaceu

Full text of DOI:10.1021/jm900839k

Products guided by the article

Product name:4-[2-cyclopentyl-1-(5-methoxy-thiazolo[5,4-b]pyridin-2-ylcarbamoyl)ethyl]benzenesulfonyl chloride

Cas No:866774-40-5

R&D Labs maybe for 866774-40-5

EGBERT CORPORATION

Contact:+86 18616952870

Address:Area
Heliosense Biotechnologies, Inc.

Contact:+86-592-5667290

Address:Xiamen Torch Hi-tech Zone Venture Weiye Building S506
Shanxi Tongji Pharmaceuticals Co., Ltd.

Contact:+86-359-3024784

Address:Xikuang South Road, Ruicheng County , Shanxi
Lyrin Industrial Corporation Limited

Contact:86-731-82571800

Address:Rm 2408,Asia Economy International Building,Shaoshan Road South,Yuhua District,Changsha,Hunan,China
Suzhou Ryan Pharmachem Technology Co.,Ltd

Contact:+86-0512-68780025

Address:B-301,No.2 Taishan Road,Suzhou New District,Jiangsu,P.R. China

Relevant to this article

A CONVENIENT APPROACH TO THE TOTAL SYNTHESIS OF (+/-) 4-DEMETHOXYDAUNOMYCINONE

Doi:10.1016/0040-4020(82)80060-4
(1982)
Synthesis of 3-Aryl-2,4-dioxo-1,2,3,4-tetrahydroquinazolines and 2-Arylamino-4-oxo-4H-3,1-benzoxazines from Methyl N-Aryldithiocarbamates

Doi:10.1055/s-1983-30357
(1983)
Stereochemistry of reactions of the inhibitor/substrates L- And D-β-chloroalanine with β-mercaptoethanol catalysed by L-aspartate aminotransferase and D-amino acid aminotransferase respectively

Doi:10.1039/b508199h
(2005)
OXOCOMPOSTELLINE AND OXOCULARINE, STRUCTURE AND SYNTHESIS

Doi:10.1016/S0040-4039(00)81907-3
(1983)
Stoichiometric and catalytic sp³ C-H/D₂ exchange reactions Of ortho- substituted benzenethiol and phenols by a ruthenium(II) complex. Effect of a chalcogen anchor on the bond cleavage reaction

Doi:10.1021/om0504598
(2005)
Doi:10.1021/jm00342a042
(1963)

Article Doi