
Journal of Organic Chemistry p. 6282 - 6286 (1994)
Update date:2022-07-29
Topics: Synthesis Catalyst Nuclear magnetic resonance (NMR) spectroscopy Nucleophilic addition Organic synthesis High-performance liquid chromatography (HPLC) Gas Chromatography-Mass Spectrometry (GC-MS) Chemical Reagents Approach Ring-closing reaction
Ahn
Kennington Jr.
DeShong
A new approach to the synthesis of monocyclic β-lactam derivatives is presented. Dipolar cycloaddition of an aldonitrone with TMS-acetylene provided a 5-(trimethylsilyl)isoxazoline. The isoxazoline was fragmented with tetrabutylammonium fluoride (TBAF) to
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