Synthesis, stability, and implications of phosphothioate agonists of sphingosine-1-phosphate receptors

DOI: 10.1016/j.bmcl.2005.07.057

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 4470 - 4474 (2005)

Update date:2022-08-04

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Authors:

Foss Jr., Frank W.

Clemens, Jeremy J.

Davis, Michael D.

Snyder, Ashley H.

Zigler, Molly A.

Lynch, Kevin R.

Macdonald, Timothy L.

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Article abstract of DOI:10.1016/j.bmcl.2005.07.057

Phosphothioates may provide metabolic stability when compared to their phosphate counterparts, while retaining the potency and efficacy as agonists at sphingosine-1-phosphate (S1P) G-protein coupled receptors. Unlike their phosphate precursors, phosphothi

Full text of DOI:10.1016/j.bmcl.2005.07.057

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