Generation of α-Acetoxyglycine Residues within Peptide Chains: A New Strategy for the Modification of Oligopeptides

Article abstract of DOI:10.1016/S0040-4020(01)88040-6

Seryl and threonyl peptides are converted into α-acetoxyglycyl peptides by treatment with lead tetraacetate.Reaction of these acetoxy derivatives or the more reactive α-chloroglycyl peptides with thiols, dithiols and carbohydrates allows the attachment of