Organic Letters p. 5609 - 5612 (2005)
Update date:2022-07-30
Topics: Synthesis Column chromatography NMR spectroscopy Mass spectrometry (MS) Minimum inhibitory concentration (MIC) Retrosynthetic analysis Structure-Activity Relationship (SAR) Structural Elucidation Natural product Biological assay Chiral synthesis Racemic mixture Enantiomeric resolution FtsZ
Urgaonkar, Sameer
La Pierre, Henry S.
Meir, Israel
Lund, Henrik
RayChaudhuri, Debabrata
Shaw, Jared T.
(Chemical Equation Presented) Two natural products have been synthesized using a ZnCl2-mediated benzylic coupling reaction. Both are potent inhibitors of the GTPase activity of FtsZ, a highly conserved protein that is essential for bacterial cytokinesis.
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