Synthesis, base pairing properties and nuclease resistance of oligothymidylate analogs containing methoxyphosphoramidate internucleoside linkages

Article abstract of DOI:10.1080/15257779408013213

A dithymidine N-methoxyphosphoramidate was synthesized and incorporated into oligothymidylate analogs. The analogs form less stable duplexes with poly dA and poly rA than the corresponding 'all diester' oligomer. The instability is more pronounced with poly rA than with poly dA. The analogs were found to be highly resistant to nucleases.

Full text of DOI:10.1080/15257779408013213

This article was downloaded by: [Computing & Library Services, University of Huddersfield]
On: 04 January 2015, At: 06:20
Publisher: Taylor & Francis
Informa Ltd Registered in England and Wales Registered Number: 1072954 Registered
office: Mortimer House, 37-41 Mortimer Street, London W1T 3JH, UK
Nucleosides and Nucleotides
Publication details, including instructions for authors and
subscription information:
http://www.tandfonline.com/loi/lncn19
Synthesis, Base Pairing Properties
and Nuclease Resistance of
Oligothymidylate Analogs Containing
Methoxyphosphoramidate
Internucleoside Linkages
S. Peyrottes a , J. J. Vasseur a , J. L. Imbach a & B. Rayner a
a Laboratoire de Chimie Bio-Organique , URA 488 du CNRS, Case
008, Universite Montpellier Il , Place Eugene Bataillon, 34095,
Montpellier, Cedex, 5, France
Published online: 24 Sep 2006.
To cite this article: S. Peyrottes , J. J. Vasseur , J. L. Imbach & B. Rayner (1994) Synthesis,
Base Pairing Properties and Nuclease Resistance of Oligothymidylate Analogs Containing
Methoxyphosphoramidate Internucleoside Linkages, Nucleosides and Nucleotides, 13:10, 2135-2149,
DOI: 10.1080/15257779408013213
To link to this article: http://dx.doi.org/10.1080/15257779408013213
PLEASE SCROLL DOWN FOR ARTICLE
Taylor & Francis makes every effort to ensure the accuracy of all the information (the
“Content”) contained in the publications on our platform. However, Taylor & Francis,
our agents, and our licensors make no representations or warranties whatsoever as to
the accuracy, completeness, or suitability for any purpose of the Content. Any opinions
and views expressed in this publication are the opinions and views of the authors,
and are not the views of or endorsed by Taylor & Francis. The accuracy of the Content
should not be relied upon and should be independently verified with primary sources
of information. Taylor and Francis shall not be liable for any losses, actions, claims,
proceedings, demands, costs, expenses, damages, and other liabilities whatsoever or
howsoever caused arising directly or indirectly in connection with, in relation to or arising
out of the use of the Content.
This article may be used for research, teaching, and private study purposes. Any
substantial or systematic reproduction, redistribution, reselling, loan, sub-licensing,
systematic supply, or distribution in any form to anyone is expressly forbidden. Terms &

Conditions of access and use can be found at http://www.tandfonline.com/page/terms-
and-conditions