An improved synthesis of 24,24-difluoro-1α,25-dihydroxyvitamin D3 from readily available vitamin D2

DOI: 10.1248/cpb.43.189

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 189 - 192 (1995)

Update date:2022-08-03

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Authors:

Ando Ando

Koike Koike

Takayama

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Article abstract of DOI:10.1248/cpb.43.189

An improved synthesis of a highly potent vitamin D₃ analog, 24,24-difluoro-1α,25-dihydroxyvitamin D₃ (1b) has been accomplished via vitamin D₂-SO₂ adducts. The introduction of fluorine atoms was performed by tre

Full text of DOI:10.1248/cpb.43.189

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