Journal of Medicinal Chemistry p. 232 - 235 (1984)
Update date:2022-08-03
Topics:
Hynes, J. B.
Yang, Y. C. S.
McGill, J. E.
Harmon, S. J.
Washtien, W. L.
A new synthetic route to 5,8-dideazaisofolic acid (IAHQ) is described which precludes the possibility of contamination due to its 4-amino counterpart 5,8-dideazaisoaminopterin.Substitution of D-glutamic acid in this synthetic scheme gave D-IAHQ.The 9-form
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