Improved Synthesis and Antitumor Evaluation of 5,8-Dideazaisofolic Acid and Closely Related Analogues

Article abstract of DOI:10.1021/jm00368a023

A new synthetic route to 5,8-dideazaisofolic acid (IAHQ) is described which precludes the possibility of contamination due to its 4-amino counterpart 5,8-dideazaisoaminopterin.Substitution of D-glutamic acid in this synthetic scheme gave D-IAHQ.The 9-form