Enantioposition-selective arylation of biaryl ditriflates by palladium- catalyzed asymmetric Grignard cross-coupling

Article abstract of DOI:10.1016/S0040-4020(98)01154-5

Asymmetric cross-coupling of achiral biaryl ditriflates with aryl Grignard reagents in the presence of 1 equiv of lithium bromide and 5 tool % of palladium complex PdCl₂[(S)-alaphos], where alaphos stands for (2- dimethylamino)propyldiphenylphosphine, gave axially chiral monophenylation products with high enantioposition-selectivity. The remaining triflate group in the monophenylation products was substituted with carboxyl and diphenylphosphino groups through palladium-catalyzed carbonylation and diphenylphosphinylation, respectively.