Chemistry of Naturally Occurring Polyamines. 8. Total Synthesis of (+)-Hypusine

DOI: 10.1021/jo00173a050

Source and publish data:

Journal of Organic Chemistry p. 5048 - 5050 (1983)

Update date:2022-08-04

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Authors:

Tice, Colin M.

Ganem, Bruce

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Article abstract of DOI:10.1021/jo00173a050

As part of a program to synthesize biologically interesting polyamines and their conjugates, we report a new approach to the synthesis of hypusine (1), an unusual amino acid constituent of the eucaryotic translation initiation factor elF-4D.Hypusine is fo

Full text of DOI:10.1021/jo00173a050

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