Synthesis of Glyceryletherphosphatides. Preparation of 2-O-Acetyl-1-O--sn-glyceryl-3-phosphorylcholin ('Oleyl PAF'), of its Enantiomer and Some Analogous, Unsaturated Compounds

Article abstract of DOI:10.1002/hlca.19830660423

Syntheses of the unsaturated glyceroletherphospholipid 1a as an olefin-analog of 'Platelet Activating Factor' (PAF) are described together with the methods for the preparation of the enantiomer 1'a, the corresponding 'lyso compounds' 1b and 1'b and their positional isomers 21a, 21'a, 26, 26', 25, 25' obtained on formally exchanging the attachment site of the functional groups at the glycerol moiety.Structural assignments and optical purity of the compounds are confirmed.