STUDIES ON INDIAN MEDICINAL PLANTS-PART LXXV NISHINDASIDE, A NOVEL IRIDOID GLYCOSIDE FROM VITEX NEGUNDO

Article abstract of DOI:10.1016/S0040-4020(01)91547-9

Two new glucosidic iridoids, designated as nishindaside (2a) and negundoside (3a), have been isolated from the leaves of Vitex negundo (Verbenaceae).The absence of a C(3)-C(4) double bond and the presence of an equatorial 3-methoxy group in 2a, the 3-methoxy-3,4-dihydro derivative of agnuside (1a), were established from 1H and 13C NMR analyses, corroborated by mass spectral fragmentation of the hexaacetate (2b).Negundoside (3a) could be concluded to be the 2'-p-hydroxy benzoyl derivative of mussaenosidic acid from the results of alkaline hydrolysis and the shifts in the signals of C-1', C-2' and C-3' in its 13C NMR spectrum.