(Imidazolylphenyl)formamidines. A structurally novel class of potent histamine H2 receptor antagonists

Article abstract of DOI:10.1021/jm00369a025

Structure-activity considerations of N(α)-guanylhistamine, the first compound found with detectable H₂-antagonist activity, led to the synthesis of a series of conformationally rigid guanylhistamine analogues, namely (imidazolylphenyl)guanidine