Generation of monospecific nanomolar tyrosine kinase inhibitors via a chemical genetic approach

DOI: 10.1021/ja983267v

Source and publish data:

Journal of the American Chemical Society p. 627 - 631 (1999)

Update date:2022-08-05

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Authors:

Bishop, Anthony C.

Kung, Chi-Yun

Shah, Kavita

Witucki, Laurie

Shokat, Kevan M.

Liu, Yi Liu, Yi

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Article abstract of DOI:10.1021/ja983267v

Selective protein kinase inhibitors are highly sought after as tools for studying cellular signal transduction cascades, yet few have been discovered due to the highly conserved fold of kinase catalytic domains. Through a combination of small molecule syn

Full text of DOI:10.1021/ja983267v

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