Bioorganic and Medicinal Chemistry Letters p. 1864 - 1868 (2006)
Update date:2022-07-29
Topics:
Liu, Bo
Liu, Mei
Xin, Zhili
Zhao, Hongyu
Serby, Michael D.
Kosogof, Christi
Nelson, Lissa T.J.
Szczepankiewicz, Bruce G.
Kaszubska, Wiweka
Schaefer, Verlyn G.
Falls, H. Douglas
Lin, Chun Wel
Collins, Christine A.
Sham, Hing L.
Liu, Gang
The synthesis and structure-activity relationships of the 4- and 6-substituents of 2,4-diaminopyrimidine-based growth hormone secretagogue receptor (GHS-R) antagonists are described. Diaminopyrimidines with 6-norbornenyl (4n) and 6-tetrahydrofuranyl (4p) substitutents were found to exhibit potent GHS-R antagonism and good selectivity (~1000-fold) against dihydrofolate reductase.
View MoreJiangyin Tenghua Import&Export Co.,Ltd.
Contact:+86-510-86263875
Address:Room 402-B,9 Yanling Road, Jiangyin,Jiangsu, China
Shandong Shouguang Songchuan Industrial Additives Co.,Ltd
Contact:+86-536-8566856
Address:Shouguang,Shandong,China
WEIFANG RICHEM INTERNATIONAL LTD
Contact:86-536-2222176
Address:weifang,shandong
Liaoyang hengye Chemical Co., Ltd.
Contact:86-419-5850866
Address:North Old Xiaoxiao Road,Yantai District, Dengta, Liaoyang, Liaoning, China
Changyi Xinxing Technology Development Co., Ltd.
Contact:0086-510-86651065(Time Zone:8),86651656
Address:94 Yingbinxilu WestRoad, Huangtu Town, Jiangyin City, Jiangsu, China
Doi:10.1016/j.inoche.2005.10.012
(2006)Doi:10.1016/S0040-4039(00)85938-9
(1983)Doi:10.1016/S0040-4039(00)85915-8
(1983)Doi:10.1016/j.tet.2015.10.082
(2015)Doi:10.1021/jo051904b
(2006)Doi:10.3184/174751915X14229898818046
(2015)