Rapid microwave-assisted syntheses of derivatives of HIV-1 entry inhibitors

Article abstract of DOI:10.1055/s-2006-926339

The direct amidation of esters with 4-amino-2,2,6,6-tetramethylpiperidine was achieved by computer-controlled microwave irradiation in toluene. The microwave protocol allowed the new amides to be prepared in three hours rather than the three days required by traditional thermal methods. Georg Thieme Verlag Stuttgart.