Bioorganic and Medicinal Chemistry Letters p. 2163 - 2169 (2006)
Update date:2022-07-31
Topics:
Freundlich, Joel S.
Yu, Min
Lucumi, Edinson
Kuo, MacK
Tsai, Han-Chun
Valderramos, Juan-Carlos
Karagyozov, Luchezar
Jacobs Jr., William R.
Schiehser, Guy A.
Fidock, David A.
Jacobus, David P.
Sacchettini, James C.
2′-Substituted analogs of triclosan have been synthesized to target inhibition of the key malarial enzyme Plasmodium falciparum enoyl acyl carrier protein reductase (PfENR). Many of these compounds exhibit good potency (EC 50 < 500 nM) against
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