Bioorganic and Medicinal Chemistry Letters p. 2738 - 2741 (2006)
Update date:2022-07-29
Topics:
Iley, Jim
Moreira, Rui
Martins, Luisa
Guedes, Rita C.
Soares, Claudio M.
Carbamate and ester derivatives of the 1,1-dioxobenzo[b]thiophen-2-ylmethyloxycarbonyl (Bsmoc) scaffold react readily with thiols via a Michael addition at rates not significantly affected by the nature of the carboxylic or carbamic acid leaving group. These Michael acceptors are irreversible inhibitors of the cysteine proteases papain and human liver cathepsin B, displaying first-order kinetics with respect to inhibitor concentration. In contrast, none of the Bsmoc derivatives inhibited porcine pancreatic elastase, a serine protease.
View MoreContact:+44 7958 511245
Address:PO Box 469, Manchester, UK
CHANGYI CITY FENGRUN FINE CHEMICAL CO.,LTD
website:http://www.fengrunhuagong.com
Contact:+86-536-7869976
Address:Changyi Coastal Economic Development Zone
Contact:Tel:+86-29-88764861 Fax:+86-29-88764861
Address:Rm#2107, Block A, Epin Meidao Building, Gaoxin Rd, Hi-Tech Zone, Xi’an, China
TIANJIN FESTO CHEMICAL CO.,LTD
Contact:86-22-25814570
Address:No.12th,5th Ave.,TEDA,Tianjin,China
Suzhou Jingye Medicine & Chemical Co., Ltd
website:http://www.jingyechem.cn
Contact:+86-512-66658588
Address:No. 88, Sanlian Street, Jinfeng Road, Suzhou New District, Jiangsu Province, P. R. China
Doi:10.1021/jm051130r
(2006)Doi:10.1039/DT9840000355
(1984)Doi:10.1055/s-2006-932484
(2006)Doi:10.1002/chem.200501078
(2006)Doi:10.1021/ja01027a006
(1968)Doi:10.1021/ja01195a033
(1947)