Application of Enzymic Baeyer-Villiger Oxidations of 2-Substituted Cycloalkanones to the Total Synthesis of (R)-(+)-Lipoic Acid

DOI: 10.1039/c39950001563

Source and publish data:

Journal of the Chemical Society. Chemical communications p. 1563 - 1564 (1995)

Update date:2022-08-05

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Authors:

Adger, Brian

Bes, M. Teresa

Grogan, Gideon

McCague, Ray

Pedragosa-Moreau, Sandrine

et al. et al.

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Article abstract of DOI:10.1039/c39950001563

Oxidation of ketones 1a-h using a monooxygenase from Pseudomonas putida NCIMB 10007 gave the lactones 2a-h in optically active form: lactone 2h was converted into (R)-(+)-lipoic acid 9.

Full text of DOI:10.1039/c39950001563

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