Bioorganic and Medicinal Chemistry Letters p. 2886 - 2890 (2006)
Update date:2022-08-03
Topics:
Sieńczyk, Marcin
Oleksyszyn, Józef
The urokinase plasminogen activator is a trypsin-like serine protease, important in tumor development. Here, we report the synthesis and biochemical evaluation of selective and potent diaryl esters of phosphonic-type inhibitors for urokinase. We have found that the substituted phenyl ester ring has a strong influence on the inhibitory activity of these compounds. This led to the most potent phosphonic inhibitor for uPA synthesized to date.
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Doi:10.1016/0008-6215(83)88457-2
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