Bioorganic and Medicinal Chemistry Letters p. 1931 - 1936 (1997)
Update date:2022-08-03
Topics:
Artico, Marino
Di Santo, Roberto
Costi, Roberta
Massa, Silvio
Scintu, Franca
Loi, Anna Giulia
De Montis, Antonella
La Colla, Paolo
Various 1-arylsulfonyl-3-(α-hydroxybenzyl)-1H-pyrroles were prepared by Friedel-Crafts reaction of 1-arylsulfonyl-1H-pyrroles with aroylchlorides in the presence of aluminum trichloride, followed by reduction of the ketones to the required carbinols. The compounds were identified as a novel class of non-nucleoside HIV-1 reverse transcriptase inhibitors characterized by the presence of a diarylcarbinol moiety, a chemical feature that strictly correlates with the anti-HIV-1 activity.
View MoreJintan Jinnuo Chemical Co., Ltd.
Contact:+86-519-80199901
Address:Room 1804, Building 1, Huacheng Business Plaza, Jintan, Jiangsu, China
Shanghai Sinofluoro Scientific Co., Ltd
Contact:+86-21-64279360
Address:Room 1006,Building 3,#58 East Xinjian Road, Shanghai ,201100,China,
Contact:+1-284-4950244
Address:Box 3069, Road Town, Tortola, British Virgin Islands
Shanghai Egoal Chemical Co.,Ltd
Contact:+86-21-50333091
Address:Yangming Garden Square 3,YangGao North Road 1188, Pudong New District, Shanghai
Hubei Onward Bio-Development Co., Ltd.
Contact:+86-718-8417012
Address:No.517,Shizhou Avenue,Enshi City,Hubei Province,China,445002
Doi:10.1039/b817274a
(2009)Doi:10.1016/j.mencom.2008.09.016
(2008)Doi:10.1021/jo00248a008
(1988)Doi:10.1016/S0040-4020(01)86911-8
(1987)Doi:10.1016/0022-328X(87)85125-2
(1987)Doi:10.1021/ja00221a030
(1988)
