Bioorganic and Medicinal Chemistry Letters p. 1931 - 1936 (1997)
Update date:2022-08-03
Topics:
Artico, Marino
Di Santo, Roberto
Costi, Roberta
Massa, Silvio
Scintu, Franca
Loi, Anna Giulia
De Montis, Antonella
La Colla, Paolo
Various 1-arylsulfonyl-3-(α-hydroxybenzyl)-1H-pyrroles were prepared by Friedel-Crafts reaction of 1-arylsulfonyl-1H-pyrroles with aroylchlorides in the presence of aluminum trichloride, followed by reduction of the ketones to the required carbinols. The compounds were identified as a novel class of non-nucleoside HIV-1 reverse transcriptase inhibitors characterized by the presence of a diarylcarbinol moiety, a chemical feature that strictly correlates with the anti-HIV-1 activity.
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