Potent, Long-Acting Luteinizing Hormone-Releasing Hormone Antagonists Containing New Synthetic Amino Acids: N,N'-Dialkyl-D-homoarginines

Article abstract of DOI:10.1021/jm00396a011

A new series of unnatural amino acids has been prepared and incorporated into antagonistic analogues of luteinizing hormone-releasing hormone (LH-RH), on the basis of the hypothesis that stabilization of a proposed phospholipid membrane interaction might