Synthesis of 5-amino-4(3H)-pyrimidinones. II. Synthesis of 5-acyl- and 5-alkylamino-3-phenyl-6-methyl-4(3H)-pyrimidinones and determination of their analgesic and antiinflammatory activities

DOI: 10.1248/cpb.31.4263

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 4263 - 4269 (1983)

Update date:2022-08-03

Topics:

Authors:

Ueda Ueda

Sakakibara

Nakagami

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Article abstract of DOI:10.1248/cpb.31.4263

N-Acylation and N-alkylation of 5-amino-6-methyl-3-phenyl-4(3H)-pyrimidinone (I) were carried out and the products were examined for analgesic and antiinflammatory activities. The reaction of I with α-bromopropionyl bromide or chloroacetyl chloride follow

Full text of DOI:10.1248/cpb.31.4263

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