Synthesis of 5-amino-4(3H)-pyrimidinones. II. Synthesis of 5-acyl- and 5-alkylamino-3-phenyl-6-methyl-4(3H)-pyrimidinones and determination of their analgesic and antiinflammatory activities

DOI: 10.1248/cpb.31.4263

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 4263 - 4269 (1983)

Update date:2022-08-03

Topics:

Authors:

Ueda Ueda

Sakakibara

Nakagami

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.31.4263

N-Acylation and N-alkylation of 5-amino-6-methyl-3-phenyl-4(3H)-pyrimidinone (I) were carried out and the products were examined for analgesic and antiinflammatory activities. The reaction of I with α-bromopropionyl bromide or chloroacetyl chloride follow

Full text of DOI:10.1248/cpb.31.4263

NII-Electronic Library Service

Products guided by the article

Product name:Acetamide, 2-chloro-N-(1,6-dihydro-4-methyl-6-oxo-1-phenyl-5-pyrimidinyl)-

Cas No:89966-52-9

R&D Labs maybe for 89966-52-9

Jurong Huaheng Natural Biological Products Factory

website:http://www.risebiochem.com

Contact:+86-13921007726

Address:Chuncheng town,Jurong city,Jiangsu province,China
Hybio Pharmaceutica Co.,Ltd

website:http://www.hybio.com.cn

Contact:+86 755 26588093

Address:No.9 Linkong West Street, Hengdian Street, Huangpi District, Wuhan City, China.
shanghai tuomiao chemicial co.,ltd.

website:https://www.tuomiaochem.com/

Contact:021 - 59853336

Address:shanghai
Tropicchem

Contact:13736652831

Address:NO.273 SHANGHAI SOUTH STREET,LUQIAO DISTRICT,ZHEJIANG PROVINCE,CHINA.
Antaeus Bio-technology Co., LTD(expird)

Contact:021-31252569

Address:shanghai pudong

Relevant to this article

Doi:10.1007/BF03046395
()
An efficient and enantioselective synthesis of suitably protected β-[1-(4-malonyl)naphthyl]-L-alanine and β-[1-(4-malonylmethyl) naphthyl]-L-alanine: Novel fluorescent and non-hydrolysable phosphotyrosine mimetics

Doi:10.1002/ejoc.200500835
(2006)
Asymmetric Aerobic Oxidative Cross-Coupling of Tetrahydroisoquinolines with Alkynes

Doi:10.1021/acscatal.7b01912
(2017)
Doi:10.1021/jo01041a505
(1963)
Doi:10.1021/jo01030a551
(1964)
On the conversion of azides to diazo compounds

Doi:10.1016/S0040-4039(97)10783-3
(1998)

Article Doi