Synthesis of 5-amino-4(3H)-pyrimidinones. II. Synthesis of 5-acyl- and 5-alkylamino-3-phenyl-6-methyl-4(3H)-pyrimidinones and determination of their analgesic and antiinflammatory activities

DOI: 10.1248/cpb.31.4263

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 4263 - 4269 (1983)

Update date:2022-08-03

Topics:

Authors:

Ueda Ueda

Sakakibara

Nakagami

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.31.4263

N-Acylation and N-alkylation of 5-amino-6-methyl-3-phenyl-4(3H)-pyrimidinone (I) were carried out and the products were examined for analgesic and antiinflammatory activities. The reaction of I with α-bromopropionyl bromide or chloroacetyl chloride follow

Full text of DOI:10.1248/cpb.31.4263

NII-Electronic Library Service

Products guided by the article

Product name:Acetamide, 2-chloro-N-(1,6-dihydro-4-methyl-6-oxo-1-phenyl-5-pyrimidinyl)-

Cas No:89966-52-9

R&D Labs maybe for 89966-52-9

Suzhou Tianma Specialty Chemicals Co.,Ltd

Contact:+86-512-68090577

Address:#199, Huayuan Rd, Mudu, Suzhou, Jiangsu, CHINA
Dalian RSD International Trade Co.,Ltd.(expird)

Contact:86-22-60875058 58610575

Address:Wantong International Areas, Hongqiao District, Tianjin, China.China
Jiangxi Dongxu Chemical Science & Technology Co.,Ltd

Contact:+86-791-86899381

Address:Nanchang, Jiangxi, China
Jingzhou TianHe Sci&Tech Chemical Co., Ltd.

Contact:86-716-8331612

Address:Jiangjin Road, #18, High-grade technology industries development district, Jingzhou city, Hubei province
Hangzhou Eastbiopharm Co.,Ltd.

Contact:+86-571-88931780

Address:Hangzhou,China

Relevant to this article

Doi:10.1007/BF03046395
()
An efficient and enantioselective synthesis of suitably protected β-[1-(4-malonyl)naphthyl]-L-alanine and β-[1-(4-malonylmethyl) naphthyl]-L-alanine: Novel fluorescent and non-hydrolysable phosphotyrosine mimetics

Doi:10.1002/ejoc.200500835
(2006)
Asymmetric Aerobic Oxidative Cross-Coupling of Tetrahydroisoquinolines with Alkynes

Doi:10.1021/acscatal.7b01912
(2017)
Doi:10.1021/jo01041a505
(1963)
Doi:10.1021/jo01030a551
(1964)
On the conversion of azides to diazo compounds

Doi:10.1016/S0040-4039(97)10783-3
(1998)

Article Doi