
Tetrahedron Letters p. 857 - 860 (1984)
Update date:2022-08-04
Topics:
Kawanami, Yasuhiro
Ito, Yoshio
Kitagawa, Toshiyuki
Taniguchi, Yoshiyuki
Katsuki, Tsutomu
Yamaguchi, Masaru
trans-2,5-Bis(methoxymethyl)- and trans-2,5-bis(methoxymethoxymethyl)pyrrolidines proved to be excellent chiral auxiliaries for the asymmetric alkylation of the corresponding carboxyamide enolates giving good chemical yield and high stereoselectivity (invariably over 95percent de), with remarkable flexibility to substrates and reaction conditions.
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