Journal of Medicinal Chemistry p. 967 - 978 (1984)
Update date:2022-08-03
Topics:
Abraham, D. J.
Kennedy, P. E.
Mehanna, A. S.
Patwa, D. C.
Williams, F. L.
In this paper we further establish the activity of two classes of small molecules, benzyloxy and phenoxy acids, as potent inhibitors of hemoglobin S (HbS) gelation.Structural modifications with a large number of each class confirm our earlier work that the highest activity is observed with compounds that contain dihalogenated aromatic rings with attached polar side chains.We have also found a halogenated aromatic malonic acid derivative to be quite active.Compounds reported in this paper are compared with other antigelling agents studied in our laboratory.Comments are made concerning the antigelling activity and binding sites of four derivatives and their effect on the allosteric mechanism of hemoglobin (Hb) function.
View MoreContact:0091-265-2313036
Address:311, ATLANTIS HEIGHTS SARABHAI MAIN ROAD,VADIWADI ,VADODARA
Contact:+86-025-52406782
Address:8 Taizishan Rd., Yanjiang Industrial Development Area, Nanjing, Jiangsu, China.
Contact:+86-15995924277
Address:WuZhongOu suzhou new south road 89
Chengdu NoVi Biotechnology Co., Ltd.(expird)
Contact:13551243286/028-81458053
Address:NO.168-1-224 JULONG ROAD WUHOU DISTRICT, CHENGDU CITY,SICHUAN PROVINCE
Contact:86-25-51817806
Address:No. 216, middle longpan road, jincheng tower, floor 21-22, nanjing ,china
Doi:10.1021/om00137a034
(1986)Doi:10.1016/j.tetlet.2006.04.156
(2006)Doi:10.1016/j.ica.2005.12.053
(2006)Doi:10.3390/molecules15042269
(2010)Doi:10.1016/j.carres.2013.11.009
(2014)Doi:10.1021/jm00146a023
(1985)
