BIOSYNTHESIS OF ANTHRAQUINONES AND RELATED COMPOUNDS IN GALIUM MOLLUGO CELL SUSPENSION CULTURES

Article abstract of DOI:10.1016/S0031-9422(00)80323-4

From Galium mollugo cell suspension cultures, 1,4-dihydroxy-3-prenyl-2-naphtholic acid methyl ester diglucoside was isolated along with anthraquinones and mollugin.Production of the diglucoside was much increased by administering 2-succinylbenzoate to the cultures.The incorporation of 2-succinylbenzoate into lucidin-3-primeveroside, mollugin and the diglucoside in the mode so far proposed for rubiaceous anthraquinones was verified by administration of 13C-labelled 2-succinylbenzoate to the cell cultures.Key Word Index - Galium mollugo; Rubiaceae; lucidin-3-primeveroside; 1,4-dihydroxy-3-prenyl-2-naphthoic acid methyl ester diglucoside; biosynthesis; cell suspension culture; 13C NMR; mass spectrometry.