Artepillin C isoprenomics: Design and synthesis of artepillin C isoprene analogues as lipid peroxidation inhibitor having low mitochondrial toxicity

DOI: 10.1016/j.bmc.2006.04.015

Source and publish data:

Bioorganic and Medicinal Chemistry p. 5721 - 5728 (2006)

Update date:2022-08-05

Topics: Design and Synthesis

Authors:

Uto, Yoshihiro

Ae, Shutaro

Koyama, Daisuke

Sakakibara, Mitsutoshi

Otomo, Naoki

Otsuki, Mamoru

Nagasawa, Hideko

Kirk, Kenneth L.

Hori, Hitoshi

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Article abstract of DOI:10.1016/j.bmc.2006.04.015

We designed and synthesized isoprene analogues of artepillin C, a major component of Brazilian propolis, and investigated the inhibitory activity on lipid peroxidation of rat liver mitochondria (RLM) and RLM toxicity based on isoprenomics. We succeeded in

Full text of DOI:10.1016/j.bmc.2006.04.015

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