Diastereoselective conjugate addition of cyanide to α,β- unsaturated oxazolidinones: Enantioselective synthesis of ent-pregabalin and baclofen

Article abstract of DOI:10.1055/s-2006-941584

Conjugate addition of cyanide to chiral α,β-unsaturated oxazolidinones catalyzed by samarium(III) isopropoxide proceeds with good diastereoselectivity. The addition products can be converted into the biologically active targets ent-pregabalin and baclofen