Novel pyrazolopyrimidopyridazinones with potent and selective phosphodiesterase 5 (PDE5) inhibitory activity as potential agents for treatment of erectile dysfunction

DOI: 10.1021/jm060265+

Source and publish data:

Journal of Medicinal Chemistry p. 5363 - 5371 (2006)

Update date:2022-08-04

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Authors:

Giovannoni, Maria Paola

Vergelli, Claudia

Biancalani, Claudio

Cesari, Nicoletta

Graziano, Alessia

Biagini, Pierfrancesco

Gracia, Jordi

Gavaldà, Amadeu

Dal Piaz, Vittorio

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Article abstract of DOI:10.1021/jm060265+

Pyrazolo[1′,5′:1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones and their analogues, potentially useful for the treatment of erectile dysfunction, were synthesized and evaluated as inhibitors of phosphodiesterase 5 (PDE5). Several compounds showed IC₅₀

Full text of DOI:10.1021/jm060265+

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